Data Science is an emerging discipline. Ubiquitous digitalization, the consequent generation of ‘big’ data, the capability to process the data, and the semiotics of its translation to innovate solutions to problems in healthcare and other domains are catalysts of its rapid growth. Digitalization is generating voluminous streams of numerical, textual, visual, auditory, haptic, and other types of data about our bodies, the things we use, and what we do where and when. Data Science is the science of translating this data into information, meaning, interpretation, knowledge, action, feedback, and learning. Systematically mining this large volume and variety of data can yield novel insights and innovative systemic solutions to current healthcare problems.