Tuberculosis (TB) remains a major global health challenge, with India being one of the high-burden countries. Despite significant progress in TB control efforts, there are still challenges to be addressed, such as underdiagnosis, drug
resistance, treatment outcomes influenced by socioeconomic factors, and the impact of the COVID-19 pandemic. Efforts to achieve TB elimination by 2025 require intensified research, innovation, and significant investment. A multi-sectoral approach involving all stakeholders is essential to end TB. India's National Tuberculosis Elimination Program has made significant strides, but challenges persist. It is crucial to maintain political commitment, utilize rapid diagnostic tests and effective treatment regimens, and ensure consistent supervision and monitoring. Collaboration and collective efforts are needed to achieve the TB elimination target by 2025.