Tuberculosis in captive Asian elephants has been a subject of interest among the experts and practitioners for the past few decades. During COVID -19 pandemic, the zoos remained closed, and the caregivers had to spend extended hours in the enclosures to help the elephants get rid of boredom and depression. Such proximity enhanced the chance of TB transmission from elephants to human bodies. Hence, effective measures are needed for the early detection of TB infection in captive elephants to curb further transmission.