By using caffeine and vanillic acid, the researchers were able to inhibit cross-reaction between isoniazid and rifampicin The physical stability and bioavailability of a fixed-dose combination (FDC) drug containing four anti-TB medicines — rifampicin, isoniazid, pyrazinamide and ethambutol has been vastly improved from 3-4 days (at 40 degree C and 75% relative humidity) to over 30 days by turning to crystal engineering.
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